Effect of Chemical Agents on Some Enzyme Activities and on the Stability of Membrane Structures
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چکیده
The effects of two chemical agents − sodium nitrite and phenobarbital (PB) applied separately or in combination, on the activity of enzymatic components of monooxigenase system of hepatocytes, the stability of liver lysosomes and peroxisomes as well as on the total activity of marker enzymes for these structures were investigated in male rats. Following the combined administration of both agents, the effects of sodium nitrite predominated. Nitrite eliminated at a considerable extent the membrane-stabilizing effect of the barbiturate, decreased its activating influence on aniline hydroxylase and potentiated PB-induced activation on systems catalyzing lipid peroxidation.
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